New Insights Into Hypertension-Associated Erectile Dysfunction

March 2012

By Kenia Pedrosa Nunes, Hicham Labazi, R. Clinton Webb

Mechanisms of erection
ED in hypertension
Antihypertensive pharmacology
Treatment of ED in hypertensive patients

Abstract
Purpose of Review—erectile Dysfunction (ed) Is Recognized as A Quality of Life Disorder That Needs to Be Treated. Currently, It Is Estimated to Affect as Many as 30 Million American Men. Thirty Percent of Hypertensive Patients Complain of Ed. the Understanding of Common Mechanisms Involved in The Etiology of Ed Associated with Hypertension, and The Investigation Of Antihypertensive Drugs that Impact Ed, Will Provide Important Tools Toward Indentifying New Therapeutic Targets that Will Improve the Quality of Life for Patients in These Conditions.
Recent Findings—hypertension and Ed Are Closely Intertwined Diseases Which Have Endothelium Dysfunction as A Common Base. During Hypertension And/or Ed, Disturbance Of Endothelium Derived Factors Can Lead to An Increase in Vascular Smooth Muscle (vsm) Contraction. Hypertension Can Also Lead to Ed as A Consequence of High Blood Pressure (bp) or Due To Antihypertensive Treatment. However, Growing Evidence Suggests Ed as An Early Sign For Hypertension. Also, Some Pde-5 Inhibitors Used to Treat Ed Can Improve Bp, but The Link Between These Conditions Has Not Been Totally Understood.
Summary—this Review Will Discuss the Interplay Between Hypertension and Ed, Exploring Newest Insights Regarding Hypertension-Associated Ed, as Well as The Effect of Antihypertensive Drugs in Ed Patients

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